NEW (ACYLOXYMETHYL)ACRYLAMIDE ESTERS, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND USING THEM AS THIOREDOXIN - THIOREDOXIN-REDUCTASE SYSTEM INHIBITORS Russian patent published in 2015 - IPC C07C235/34 A61K31/165 A61P35/00 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula (1) or their pharmaceutically acceptable salts, wherein in formula (1) R1 means a linear or branched C₁-C₈ alkyl group, phenyl or benzyl; R2 means hydrogen or C₁-C₈ alkyl-2-formamide acetate group; R3 means acyl group of carboxylic acid specified in groups of 2,6-dichlorbenzoic or 2,6-di(trifluormethyl)benzoic acid. The invention also refers to using the compounds of formula (1) and a pharmaceutical composition containing them.

EFFECT: compounds of formula (1) possessing inhibitory activity on the thioredoxin - thioredoxin-reductase system.

4 cl, 2 dwg, 4 tbl