(2R)-2-[(4-SULPHONYL)AMINOPHENYL]PROPANAMIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2012 - IPC C07C311/13 C07C311/14 C07C311/21 C07C311/29 C07D277/46 C07D333/34 A61K31/18 A61K31/381 A61K31/426 A61P11/00 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new (2R)-2-phenylpropanamide derivatives of formula (I) or their pharmaceutically acceptable salts having an ability to inhibit CXCL1-induced chemiotaxis of human multiform nuclear leucocytes (PMNs), to a based pharmaceutical composition, to applying them for preparing a drug and a methods for making them. wherein R is specified from H, C₁-C₅-alkyl, C₃-C₆-cycloalkyl, thiazol substituted by trifluoromethyl, a residue of formula -CH₂-CH₂-O-(CH₂-CH₂O)nR^", wherein R" represents H or C₁-C₅-alkyl, n is equal to an integer within 0 to 2, or R together with an NH-group whereto attached is a radical group of primary amides of natural amino acid such as (2S)-2-aminopropanamide; R' is specified in linear or branched C₁-C₅-alkyl, C₃-C₆-cycloalkyl, trifluoromethyl, phenyl, optionally substituted by a group specified in halogen, C₁-C₅-alkyl, C₁-C₅-alkoxy and trifluoromethyl; unsubstituted benzyl; thiophen.

EFFECT: preparing the new pharmaceutical composition.

9 cl, 1 tbl