NOVEL DIHYDRO-OXAZOLOBENZODIAZEPINE COMPOUNDS, METHOD OF OBTAINING THEREOF AND THEREOF-CONTAINING PHARMACEUTICAL COMPOSITIONS Russian patent published in 2016 - IPC C07D498/04 A61K31/551 A61P25/18 A61P25/24 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I) or their pharmaceutically acceptable acid addition salts, where R¹ represents hydrogen atom or linear or branched (C₁-C₄)alkyl group; R² represents linear or branched (C₁-C₄)alkyl group; R³ represents aryl or heteroaryl group; where aryl group represents naphthyl group, optionally substituted with one or several identical or different groups, selected from halogen atoms; linear or branched (C₁-C₆)alkyl group, which is non-substituted or is substituted with one or several halogen atoms; linear or branched (C₁-C₆)alkoxygroup; cyanogroup; or aminogroup, which is non-substituted or is substituted with one or two linear or branched (C₁-C₆)alkyl groups; and heteroaryl group represents bicyclic or tricyclic group, in which at least one of rings is aromatic, which contains from 1 to 3, identical or different, heteroatoms, selected from nitrogen, oxygen and sulphur, optionally substituted with one or several identical or different groups, selected from halogen atoms; linear or branched (C₁-C₆)alkyl group, which is non-substituted or is substituted with one or several halogen atoms; linear or branched (C₁-C₆)alkoxygroup; cyanogroup; or aminogroup, which is non-substituted or is substituted with one or two linear or branched (C₁-C₆)alkyl groups. Invention also relates to method of obtaining formula (I) compounds, pharmaceutical composition, containing formula (I) compound as active ingredient, and application of formula (I) compounds for preparation of medications.

EFFECT: formula (I) compounds, possessing selective activity with respect to α₅ subunit of GABA_A receptor.

16 cl, 5 dwg, 56 ex