ANTIVIRAL HETEROCYCLIC COMPOUNDS Russian patent published in 2016 - IPC C07D401/04 C07D403/04 C07D487/04 A61K31/517 A61K31/519 A61P31/14 A61P37/02 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (I), which possess the properties of HCV NS5B RNA-polymerase inhibitor. The compounds may be used for treating or preventing an infection caused by hepatitis C virus (HCV). In formula (I), X represents CH or N, R¹ is specified in a group consisting of R^1a, R^1c : wherein R^1a is optionally substituted by C_1-6alkyl, C_1-6alkoxy or hydroxy, and wherein R^1c is optionally substituted by C_1-6alkyl; R² represents (a) aryl specified in phenyl, or (b) NR^aR^b, wherein the above aryl is optionally substituted by (CH₂)_nNR^cR^d; R^a and R^b together with a nitrogen atom, to which they are attached, represent 5-merous heterocyclic amine substituted by (CH₂)_nNR^cR^d group, wherein n means a number from zero to two; R^c and R^d independently represent hydrogen, O₂SR⁴, wherein R⁴ represents C₁₆alkyl; R³ represents CR^4aR^4bR^4c, wherein: 1) R^4a, R^4b and R^4c are independently specified in C_1-3alkyl.

EFFECT: producing the compounds for treating or preventing an infection caused by hepatitis C virus (HCV).

14 cl, 2 tbl, 9 ex