CFTR REGULATORS AND THEIR APPLICATION METHODS Russian patent published in 2021 - IPC C07D251/52 C07D403/12 C07D413/12 C07D417/12 A61K31/53 A61P1/10 A61P1/16 A61P11/00 A61P27/02 A61P27/04 

FIELD: biochemistry.

SUBSTANCE: invention relates to a compound of Formula I or its pharmacologically acceptable salt. In Formula I X is -O-; R² is C₂-C₄ halogenalkyl, substituted with at least four fluorine atoms; R³ is hydrogen; R⁴ is -CH₃ or -CH₂CH₃; R⁵ is H; and R¹, R⁶, R⁷, R⁸ and R⁹ represent hydrogen. The invention also relates to pharmaceutical compositions and to methods of treatment.

EFFECT: new compounds of Formula I have been obtained that activate the cystic fibrotic transmembrane conduction regulator (CFTR), which may be useful for increasing lacrimation and in the treatment of constipation, dry eye syndrome, cholestatic liver disease, pulmonary disease or disorder.

(I).

23 cl, 60 dwg, 5 tbl, 6 ex