CFTR REGULATORS AND METHODS FOR USE THEREOF Russian patent published in 2021 - IPC A61K31/433 C07D285/135 C07D417/12 A61P27/04 A61P1/10 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a method for activating a cystic fibrous transmembrane conductance regulator (CFTR), involving bringing CFTR in contact with a compound of structural formula (I) or with its pharmaceutically acceptable salt, where Ar is substituted phenyl, where substitutes are selected from -OCH₃, -OC₂H₅, chlorine, fluorine or bromine, or Ar is unsubstituted thiophenyl; L¹ and L² independently represent unsubstituted C₁-C₃ alkylene; R¹ denotes hydrogen; R² is hydrogen; R³ is -OR^3A; R⁴ is -OR^4A; R⁵ denotes hydrogen; R^3A and R^4A independently represent unsubstituted C₁-C₂ alkyl.

(I)

EFFECT: said method can be used in medicine for treating diseases and disorders associated with activation of CFTR.

14 cl, 1 tbl, 5 ex, 45 dwg