FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to immunology. Disclosed is an antibody capable of binding to a human beta-fibrotic protein, and an antigen-binding fragment thereof. Also provided are: a polynucleotide, an expression vector, a cell, a pharmaceutical composition, methods of improving glucose metabolism parameters and various metabolic parameters, methods of treating type 2 diabetes mellitus, obesity, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD) and a method of inducing FGF19- and/or FGF21-like signal transmission.
EFFECT: present invention can be used for treating various beta-klotho related diseases, such as obesity, dyslipidemia, and so forth.
35 cl, 6 dwg, 31 tbl, 9 ex
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