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(19)

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2 630 660

(13)

(51)

IPC

C07K19/00(2006-01-01)

C07K14/195(2006-01-01)

C07K16/12(2006-01-01)

A61K39/02(2006-01-01)

A61P37/04(2006-01-01)

(21) (22)

Application

2013152691, 2012-05-04

(24)

Start date

2012-05-04

(22)

Actual filing date

2012-05-04

(45)

Published

2017-09-11

(72)

Inventor

Andres GerbertKasagolda Valribera DavidDyufel KhartmutGerg MikhelSholts KristianShreml Mikhel

(73)

Holder

F. Hoffmann-La Roche Ag

HYBRID POLYPEPTIDE, PRESENTING AMINO ACID SEQUENCES, AND ITS APPLICATION Russian patent published in 2017 - IPC C07K19/00 C07K14/195 C07K16/12 A61K39/02 A61P37/04

Abstract RU 2630660 C2

FIELD: biotechnology.

SUBSTANCE: hybrid polypeptides are produced, that are capable of inducing an immune response against X₁ in an animal other than a human, according to formula I and II NH₂-S₂-X₁-COOH (formula I) NH₂-S₄-X₂-S₃-S₂-X₁-S₁-S₀-COOH (formula II), where X₁ contains an amino acid sequence that is a target antigen or an immunogenic sequence and optionally includes a linker or adapter sequence, denotes a peptide bond, S₁ and S₂ are a pair of sequences of SEQ ID NO: 3 and 2, respectively.

EFFECT: invention allows to effectively achieve an immune response to the target antigen and to obtain antibodies to the target antigen.

14 cl, 40 dwg, 2 tbl, 17 ex

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RU 2 630 660 C2

Authors

Andres Gerbert

Kasagolda Valribera David

Dyufel Khartmut

Gerg Mikhel

Sholts Kristian

Shreml Mikhel

Dates

2017-09-11—Published

2012-05-04—Filed