METHOD FOR DIFFERENTIATING IN VITRO POSTVACCINAL AND INFECTIOUS BRUCELLOSIS ACCORDING TO DEGREE OF BODY HYPERSENSITIVITY TO BRUCELLA Russian patent published in 2016 - IPC G01N33/48 

Abstract RU 2574207 C1

FIELD: medicine.

SUBSTANCE: described method involves incubating whole heparinised blood with the liquid brucellar allergen Brucellin and anti-CD63+ basophil degranulation marker monoclonal antibodies. Thereafter, a flow cytometry procedure is applied to count the activated basophils, which is supposed to fall within the range from 5.1% to 19% in individuals given with brucellosis vaccine, and from 19.1% or more - in those who suffer Brucellosis.

EFFECT: invention is applicable in the differential diagnosis of postvaccinal and infectious processes accompanying brucellosis.

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RU 2 574 207 C1

Authors

Ponomarenko Dmitrij Grigor'Evich

Rakitina Ekaterina L'Vovna

Logvinenko Ol'Ga Vasil'Evna

Sarkisjan Nushik Saakovna

Kostjuchenko Marina Vladimirovna

Kulichenko Aleksandr Nikolaevich

Ljamkin Gennadij Ivanovich

Golub' Ol'Ga Grigor'Evna

Berdnikova Tat'Jana Vasil'Evna

Dates

2016-02-10Published

2015-02-05Filed