FIELD: chemistry.
SUBSTANCE: compounds demonstrate metabolic stability and do not possess hepatotoxicity, that is are safe therapeutic medications for treating diseases, involving B-cells or mast cells. Compounds can be used in treatment of allergic disease, autoimmune disease, inflammatory disease, thromboembolic disease or cancer, in particular in treatment of non-Hodgkin's lymphoma. In general formula (I) 
L represents (1) -O-, (5) -NH-, (6) -C(O)-, (7) -CH2-O-, (8) -O-CH2- or (9) -CH2-; R1 represents (1) halogen atom, (2) C1-4alkyl group, (3) C1-4alkoxy group, or (4) C1-4halogenalkyl group ; cycle 1 represents cyclic group, selected from phenyl, C4-7cycloalkyl and pyridinyl, which can be substituted with 1-2 substituents, each of which is independently selected from the group, consisting of (1) halogen atoms, (2) C1-4alkyl groups, (3) C1-4alkoxy groups and (5) C1-4halogenalkyl groups, where in case of presence of two substituents in cycle 1 said substituents can form 4-7-membered cyclic group together with atoms in cycle 1, which said substituents are bound to, containing 2 oxygen atoms in cyclic group; cycle 2 represents 4-7-membered nitrogen-containing saturated heterocycle, which has from one to two substituents -K-R2; K represents -C(O)- (where left bond is connected with cycle 2); R2 represents (2) C2-4alkenyl or (3) C2-4alkinyl group, each of which can be substituted with 1-2 substituents, each of which is independently selected from the group, consisting of (1) NR3R4, (2) halogen atoms, (3) CONR5R6, (4) CO2R7 and (5) OR8; each of R3 and R4 independently represents (1) hydrogen atom or (2) (2) C1-4alkyl group, which can have substituent OR9 or CONR10R11; R3 and R4 together with nitrogen atom, they are bound to, can form 4-7-membered nitrogen-containing saturated heterocycle, which contains nitrogen atom and, optionally, one more heteroatom, selected from nitrogen, sulphur and oxygen, which can be substituted with oxo group or hydroxyl group; each of R5 and R6 independently represents (1) hydrogen atom; R7 represents (1) hydrogen atom or (2) C1-4alkyl group; R8 represents (1) hydrogen atom, (2) C1-4alkyl group or (4) benzotriazolyl group; R9 represents (1) hydrogen atom or (2) C1-4alkyl group; each of R10 and R11 independently represents (1) hydrogen atom; n represents 0 or 1; m represents integer number from 0 to 2.
EFFECT: invention relates to novel compounds of general formula (I), which possess Btk-selective inhibiting activity (Bruton's tyrosine kinase inhibitors).
15 cl, 3 tbl, 27 ex
