FIELD: chemistry.
SUBSTANCE: invention relates to 5-aryl-pyrimidoindolizine or 5-aryl-pyrimidopyrrolizine compound of formula I, in which R1 denotes H, methyl or methylidene; L is -O-, -C(=O) NH- or -C(=O)NHCHR2-, where R2 is substituted C1-C3 alkyl and the substitute in R2 is C1-C3 alkoxy; m is 0 or 1; Ar represents substituted or unsubstituted C6 aryl, substituted or unsubstituted 6-membered heteroaryl containing one heteroatom N, wherein the substituent in Ar represents halogen or trifluoromethyl, A is carbonyl, sulfonyl or where R3 and R4 independently represent hydrogen or C1-C3 alkyl, or R3, R4 together with a carbon atom attached thereto form C3-C5 cycloalkyl; n is equal to 1; T is
or
; R5, R6 and R7 are independently selected from a group consisting of hydrogen, cyano and substituted or unsubstituted C1-C5 alkyl; the substitute in R5, R6 or R7 is dimethylamino; R8 is methyl. Invention also relates to a method of producing, to a pharmaceutical composition and to use of 5-aryl-pyrimidoindolizine or 5-aryl-pyrimidopyrroline compound for preparing a drug for treating human lymphoma related to signal transduction of BTK kinase.
EFFECT: technical result: obtaining novel 5-aryl-pyrimidoindolizine and 5-aryl-pyrimidopyrrolizine compounds of formula I, having inhibitory activity on BTK.
8 cl, 24 ex
Title | Year | Author | Number |
---|---|---|---|
QUINOLYL PYRROLE PYRIMIDYL CONDENSED COMPOUND OR SALT THEREOF | 2013 |
|
RU2581039C1 |
METHOD FOR SYNTHESIS OF NOVEL CHIRAL LIGAND, METAL CHELATE, VARIOUS UNNATURAL AMINO ACIDS, MARAVIROC AND MAIN INTERMEDIATE COMPOUNDS THEREOF | 2017 |
|
RU2727723C1 |
COMPOUNDS BASED ON TRIAZOLOPYRIMIDINE AND THEIR SALTS, COMPOSITIONS BASED ON THEM AND WAYS OF THEIR USE | 2020 |
|
RU2809821C2 |
FLUORINATED COMPOUND OF CYCLOPROPYLAMINE, THE METHOD OF PREPARATION, THE PHARMACEUTICAL COMPOSITION AND ITS USE | 2017 |
|
RU2746323C2 |
PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF | 2014 |
|
RU2712220C2 |
5-AROMATIC ALKYNYL-SUBSTITUTED BENZAMIDE COMPOUND AND METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 2016 |
|
RU2695371C2 |
PURINONE COMPOUNDS AS KINASE INHIBITORS | 2013 |
|
RU2655388C2 |
ISOINDOLINE COMPOUND, PRODUCTION METHOD, PHARMACEUTICAL COMPOSITION AND THEIR USE | 2019 |
|
RU2813232C2 |
PYRIMIDINE DERIVATIVES AS BTK INHIBITORS AND USE THEREOF | 2016 |
|
RU2743040C2 |
NOVEL QUINOLINE-SUBSTITUTED COMPOUND | 2014 |
|
RU2689158C2 |
Authors
Dates
2020-05-22—Published
2017-11-24—Filed