DERIVATIVE 6-CARBONITRILE DIPYRIDOPYRROLES AND APPLICATION THEREOF IN CANCER TREATMENT Russian patent published in 2016 - IPC C07D471/14 A61K31/4427 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to novel heterocyclic compounds of general formula or to its pharmaceutically acceptable salts, where X is CR⁴; Z is CR⁸; R² is H; R³ is H, halo or R⁹; R⁴: H, -(CR¹⁴R¹⁵)_nNR¹¹R¹², -(CR¹⁴R¹⁵)_nOR¹¹, monocycle, possessing 4-6 ring members, 1-2 of which represent heteroatoms, selected from nitrogen and oxygen, or bicycle, possessing 7-8 ring atoms, 1-2 of which represent heteroatoms, selected from nitrogen, where said monocycle and bicycle are optionally substituted by one group R¹³; each n independently represents 0-2; R⁵: H, -(CR¹⁴R¹⁵)_nNR¹¹R¹², -(CR¹⁴R¹⁵)_nOR¹¹; R⁶: H, CN or pyrazolyl, optionally substituted by one group R¹³; R⁸ is H; R⁹ is C1-6-alkyl; R¹¹ and R¹²: H, C1-6-alkyl, C3-6-cycloalkyl, monocycle, possessing 4-7 ring members, 1 of which represents heteroatom, selected from nitrogen and oxygen, or bicycle, possessing 7-8 ring atoms, 1 of which represents nitrogen heteroatom, where said alkyl, cycloalkyl, monocycle and bicycle are optionally substituted by from one to two groups R¹³; R¹¹ and R¹² together with N atom, which they are bound to, optionally form 4-7-membered monocyclic or bicyclic ring, possessing additional 0-1 heteroatoms, selected from O and N, said ring can be optionally substituted by from one to two groups R¹³; R¹³ represents halo, oxo, -(CR¹⁴R¹⁵)_nC(=Y')R¹⁶, -(CR¹⁴R¹⁵)_nNR¹⁶R¹⁷, -(CR¹⁴R¹⁵)_nOR¹⁶, -(CR¹⁴R¹⁵)_nNR¹⁶C(=Y')R¹⁷ or R¹⁶; R¹⁴ and R¹⁵ are H; R¹⁶ and R¹⁷: H, C1-6-alkyl, monocycle, possessing 4-6 ring members, 1-2 of which represent heteroatoms, selected from nitrogen and oxygen, or bicycle, possessing 7-8 ring atoms, 1 of which represents nitrogen heteroatom, where said alkyl, monocycle or bicycle are optionally substituted by from one to three groups R¹⁸; R¹⁶ and R¹⁷ together with N atom, which they are bound to, optionally form 5-6-membered ring, possessing additional 0-1 heteroatoms, selected from O, said ring can be optionally substituted by from one to two groups R¹⁸; R¹⁸: C1-6-alkyl, C3-6-cycloalkyl, monocycle, possessing 4-5 ring members, 1 of which represents heteroatom, selected from nitrogen and oxygen, or bicycle, possessing 7-8 ring atoms, 1-2 of which represent heteroatoms, selected from nitrogen, halo, CF₃, -(CR¹⁹R²⁰)_nOR²³, -(CR¹⁹R²⁰)_nS(O)₂R²³ or -(CR¹⁹R²⁰)_nS(O)₂NR²³R²⁴, where said alkyl is optionally substituted by one group R²¹; R¹⁹ and R²⁰ are H; R²³ and R²⁴: H, C1-6-alkyl; each R²¹ independently represents H or halogen; Y' represents O. Invention also relates to intermediate compounds, pharmaceutical composition based on formula (i) compound, method of inhibiting abnormal cell growth or treatment of hyperproliferative disorders and method for treatment of tumour disease, based on application of formula (I) compound, application of formula (I) compound.

EFFECT: obtained are novel compounds, useful in treatment of hyperproliferative disorders.

29 cl, 1 dwg, 7 tbl, 180 ex