METHOD OF EVALUATING THE EFFECTIVENESS OF ANTI-TUBERCULOSIS THERAPY IN PATIENTS WITH GENITAL TUBERCULOSIS Russian patent published in 2016 - IPC G01N33/48 G01N33/53 

Abstract RU 2577723 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is a method of evaluating the effectiveness of therapy of genital tuberculosis comprising control Immunoassays, characterized in that at the end of the initial phase of therapy is carried out 1st control, which comprises determining the stimulation index of interferon-gamma (IFN-γ) with purified tuberculin (PPD-L), the definition of the levels of specific immunoglobulins (IgA, IgM) for mycobacterium tuberculosis (MBT) by enzyme-linked immunosorbent assay (ELISA), and the 2nd control is carried out through the 6-11 months after the end of the main course of therapy, In the case when a stimulation index IFNγ with PPD-L at the end of the intensive phase of TB treatment was higher than 7, 8 - only IFNγ with PPD-A, if the optical density IgM to MBT has a 0.600 - only IgM to MBT, when the optical density at MBT to IgA was more than 0.450 - control is performed only to IgA; while the results of controlled studies recommend an extension or correction, or the end of therapy.

EFFECT: invention provides a more accurate assessment of TB therapy.

1 cl, 2 ex, 1 tbl

Similar patents RU2577723C2

Title Year Author Number
COMPLEX DIAGNOSTIC TECHNIQUE IN ACTIVE GENITAL TUBERCULOSIS IN FEMALES 2011
  • Mordyk Anna Vladimirovna
  • Plekhanova Marija Aleksandrovna
  • Patsula Jurij Ivanovich
  • Jakovleva Anastasija Alekseevna
RU2473089C1
METHOD FOR ASSESSING TUBERCULOSIS ACTIVITY IN CHILDREN AND ADOLESCENTS 2011
  • Patsula Jurij Ivanovich
  • Plekhanova Marija Aleksandrovna
  • Mordyk Anna Vladimirovna
  • Glinskikh Ol'Ga Sergeevna
RU2498311C2
DIAGNOSTIC TECHNIQUE FOR FEMALE GENITAL TUBERCULOSIS IN STERILE WOMEN 2013
  • Klinyshkova Tat'Jana Vladimirovna
  • Plekhanova Marija Aleksandrovna
  • Frolova Natal'Ja Borisovna
  • Jakovleva Anastasija Alekseevna
  • Dolgikh Tat'Jana Ivanovna
RU2548765C1
METHOD FOR TREATMENT OF PULMONARY TUBERCULOSIS 2001
  • Zabolotnykh N.V.
  • Ivanova L.A.
  • Vinogradova T.I.
  • Pavlova M.V.
  • Vasil'Eva S.N.
  • Vasil'Eva G.Ju.
  • Simbirtsev A.S.
  • Kolobov A.A.
  • Pigareva N.V.
RU2229892C2
METHOD FOR TREATING PULMONARY TUBERCULOSIS AT PREDOMINANTLY PRODUCTIVE TYPE OF TISSUE REACTION 2000
  • Ivanova L.A.
  • Vinogradova T.I.
  • Zabolotnykh N.V.
  • Archakova L.I.
  • Chuzhova N.M.
  • Pavlova M.V.
  • Knoring B.E.
  • Simbirtsev A.S.
RU2204409C2
METHOD FOR SELECTING SHORTENED CHEMOTHERAPY REGIMENS IN THE TREATMENT OF RESPIRATORY TUBERCULOSIS IN CHILDREN FROM FOCI WITH MULTIDRUG RESISTANCE OF THE PATHOGEN 2022
  • Gubkina Marina Fedorovna
  • Petrakova Irina Yurevna
  • Khokhlova Yuliya Yurevna
  • Sterlikova Svetlana Sergeevna
  • Yukhimenko Natalya Valentinovna
RU2784464C1
METHOD FOR TREATMENT OF DESTRUCTIVE AND PROGRESSING LUNG TUBERCULOSIS FORMS CAUSED BY DRUG-RESISTANT STRAINS OF MYCOBACTERIUM TUBERCULOSIS 2000
  • Ivanova L.A.
  • Chuzhova N.M.
  • Archakova L.I.
  • Pavlova M.V.
  • Knoring B.E.
  • Smirnov M.N.
RU2215538C2
METHOD FOR EVALUATING ACTIVITY OF TUBERCULOSIS INFECTION IN CHILDREN AND ADOLESCENTS 2015
  • Plekhanova Mariya Aleksandrovna
  • Patsula Yurij Ivanovich
  • Aksenova Valentina Aleksandrovna
  • Krivtsova Lyudmila Alekseevna
  • Lunin Vladimir Glebovich
  • Tkachuk Artem Petrovich
  • Gintsburg Aleksandr Leonidovich
RU2586279C1
METHOD FOR CHOOSING THERAPEUTIC APPROACH FOR PATIENTS WITH NEWLY DIAGNOSED INFILTRATIVE PULMONARY TUBERCULOSIS 2015
  • Sutjagina Dina Andreevna
  • Shprykov Aleksandr Sergeevich
  • Shakhov Boris Evgenevich
RU2602683C1
METHOD FOR TREATING THE CASES OF TUBERCULOSIS 2002
  • Pastukhov V.N.
  • Kravchenko M.A.
  • Olin B.G.
  • Klejn A.V.
  • Mironova A.L.
RU2212240C1

RU 2 577 723 C2

Authors

Mordyk Anna Vladimirovna

Jakovleva Anastasija Alekseevna

Dates

2016-03-20Published

2014-07-10Filed