FIELD: chemistry.
SUBSTANCE: invention relates to the method of producing the compound C: , which includes one- to three-step selective acylation of the hydroxyl group in the first position and in the eleventh position of the compound of formula B1: , with an acylating agent in a solvent selected from N-methyl-2-pyrrolidinone and N,N-dimethylacetamide, in the presence of a base selected from 2,4,6-collidine and 2,6-lutidine, or in the absence of a base.
EFFECT: method enables to selectively obtain the compound C with high output.
13 cl, 1 dwg, 5 tbl, 25 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF OBTAINING PYRIPYROPENE DERIVATIVES | 2010 |
|
RU2532441C2 |
METHOD OF PRODUCING PYRIPYROPENE DERIVATIVES AND INTERMEDIATE PRODUCTS FOR PRODUCTION THEREOF | 2008 |
|
RU2494101C2 |
METHOD FOR OBTAINING TRIAZOLOPYRIDINE COMPOUND | 2017 |
|
RU2752384C2 |
REGIOSELECTIVE ACYLATION OF RAPAMYCIN AT C-42 POSITION | 2012 |
|
RU2603261C2 |
METHOD OF SYNTHESIS OF CRYSTALLINE SOLVATE, CRYSTALLINE SOLVATE OF 6-HYDROXY-2-(4-HYDROXYPHENYL)-3-[4-(2-PIPERIDINEETH- -OXY)BENZOYL]BENZO[B]THIOPHENE HYDROCHLORIDE | 1995 |
|
RU2108331C1 |
NONSOLVATED CRYSTALLINE 6-HYDROXY-2-(4-HYDROXYPHENYL)-3-[4-(2- -PIPERIDINOETHOXY)-BENZOYL]-BENZO-[B]-THIOPHENE HYDROCHLORIDE SHOWING ANTIESTROGENIC AND ANTIANDROGENIC ACTIVITY, PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2104278C1 |
THIAZOLIDINE COMPOUNDS, METHOD OF PREPARATION THEREOF, METHOD OF REDUCING SUGAR CONTENT IN BLOOD OF MAMMALS | 1992 |
|
RU2095354C1 |
DERIVATIVES OF OXAZOLIDINEDIONE, THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2144030C1 |
DERIVATIVES OF DITHIOLANE, MEDICINAL AGENTS | 1998 |
|
RU2169731C2 |
0 |
|
SU560530A3 |
Authors
Dates
2016-03-27—Published
2010-11-10—Filed