METHOD OF PRODUCING 1,2,4-TRIOXOLANES Russian patent published in 2016 - IPC C07D323/06 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a new tetracyclic 1,2,4-trioxolanes with formula I, where Ia: R=H, R₁=CH₃, m=n=1; Ib: R=1-cyclohexenyl, R₁=H, m=n=1; Ic: R=R₁=H, m=1, n=2; Id: R=R₁=H, m=n=0; Ie: R=R₁=H, m= n=1, on the basis of 1,5-diketones of the general formula II and their cyclic form melts IIIa, e, wherein R, R₁, m and n have defined above values; which consists in the oxidation of said initial compounds in 28% aqueous solution of hydrogen peroxide in an organic solvent (diethyl ether, ethanol) in the presence of catalytic amounts of acid (HCl, H₂SO₄) or BF₃·OEt₂ at room temperature with a molar ratio of 1,5-diketone:H₂O₂=1:1.5-3.

EFFECT: development of efficient and environmentally friendly method of producing previously unknown tetracyclic 1,2,4-trioxolanes with specified composition, which can be used as starting substances in organic synthesis, as initiators for radical polymerisation, as well as in pharmacology and medicine as a biologically active compounds with antimalarial, antiparasitic and anticancer activity.

4 cl, 20 dwg, 5 ex, 1 tbl