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2 578 855

(13)

(51)

IPC

A61N5/10(2006-01-01)

A61K31/282(2006-01-01)

A61K31/7068(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2015110760/14, 2015-03-26

(24)

Start date

2015-03-26

(22)

Actual filing date

2015-03-26

(45)

Published

2016-03-27

(72)

Inventor

Rasulov Arsen OsmanovichKuzmichev Dmitrij VladimirovichGordeev Sergej SergeevichTkachev Sergej IvanovichFedjanin Mikhail JurevichGlebovskaja Valerija VladimirovnaAliev Vjacheslav AfandievichMamedli Zaman ZaurovichKulushev Vadim MaratovichTamrazov Rasim Ilkhamovich

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Nauchnoe Uchrezhdenie Onkologicheskij Nauchnyj Tsentr Imeni N.N. Blokhina" Im. N.N. Blokhina")

METHOD OF TREATING LOCALLY ADVANCED RECTAL CANCER Russian patent published in 2016 - IPC A61N5/10 A61K31/282 A61K31/7068 A61P35/00

Abstract RU 2578855 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, oncology and concerns a method of treating locally advanced rectal cancer (RC). One performs teletherapy (RTT), chemotherapy capecitabine and oxaliplatin, verified chemotherapy followed by a surgery. Note here that conformable large fraction RTT is performed in a single basic dose of 4 Gy to total basic dose of 40 Gy, 3 times a week, total 10 sessions. Simultaneously with the course of radiation therapy, a course of chemotherapy capecitabine in dosage 850 mg/m² twice a day every 12:00. Then 2 courses of consolidating chemotherapy every 7 days: oxaliplatin in dosage 130 mg/m² intravenously on the first day of each course and capecitabine in a daily dose 2,000 mg/m² inside twice a day every 12:00 during 14 days. Total duration of treatment of 8 weeks.

EFFECT: method provides evident therapeutic pathomorphosis at T3 and T4 stages of RC, increase of frequency of complete therapeutic pathomorphism, low degree of toxicity.

1 cl, 2 ex

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RU 2 578 855 C1

Authors

Rasulov Arsen Osmanovich

Kuzmichev Dmitrij Vladimirovich

Gordeev Sergej Sergeevich

Tkachev Sergej Ivanovich

Fedjanin Mikhail Jurevich

Glebovskaja Valerija Vladimirovna

Aliev Vjacheslav Afandievich

Mamedli Zaman Zaurovich

Kulushev Vadim Maratovich

Tamrazov Rasim Ilkhamovich

Dates

2016-03-27—Published

2015-03-26—Filed