FIELD: medicine.
SUBSTANCE: combined vaccine contains a first BVDV of the first type carrying E2 BVDV gene of the above first type, a second BVDV of the first type, wherein this E2 BVDV gene of the above first type is substituted by E2 BVDV gene of the second type, and a pharmaceutically acceptable carrier. The group of inventions also refers to a method for producing the above BVDV vaccine.
EFFECT: using the chimeric BVDV vaccine containing original E2 gene, and also the second E2 gene of the other type ensures equal expression levels of both E2 genes.
12 cl, 4 ex, 1 tbl, 6 dwg
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