FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology, virology and veterinary. An attenuated recombinant classical swine fever virus (CSFV) is described. Modification is carried out by progressively mutating a portion of the E2 gene of the highly pathogenic strain Brescia. As a result, two to six amino acids on the section 829-837 are replaced with two to six amino acids which are characteristic for the heterologous E2 glycoprotein of the Bovine Viral Diarrhea Virus (BVDV). A classical swine fever vaccine is also obtained based on the obtained attenuated CSFV. The invention can be used in veterinary.
EFFECT: classical swine fever vaccine is obtained.
7 cl, 7 dwg, 4 tbl, 7 ex
| Title |
Year |
Author |
Number |
| RECOMBINANT CLASSICAL SWINE FEVER VIRUS (CSFV), WHICH CONTAINS MODIFIED PROTEIN E2, AND CREATION METHODS OF ABOVE DESCRIBED RECOMBINANT CSFV |
2009 |
- Kortekas Erun Aleksander
- Vlut Rianka Petronella Marija
|
RU2501854C2 |
| MUTANT PESTIVIRUS WITH MUTATIONS IN Core GENE AND AREA NS3 AND VACCINE ON ITS BASIS |
2009 |
- Til' Khejnts-Jurgen
- Rjumenapf Khans Till'Mann
- Khajmann Manuehla
|
RU2483106C2 |
| IMPROVED DIAGNOSTIC TEST FOR CSFV ANTIBODIES |
2014 |
|
RU2689143C1 |
| PESTIVIRUSES |
2015 |
- Van Der Hoek, Cornelia, Maria
- Deijs, Martin
- Schrier, Carla, Christina
- Guelen, Lars
- De Groof, Ad
|
RU2710041C2 |
| MINUS-CHAIN-CONTAINING ATTENUATED VIRUSES WITH CHANGED ANTAGONISTIC ACTIVITY AS REGARDS FOR INTERFERON FOR APPLYING AS VACCINES AND PHARMACEUTICAL SUBSTANCES |
1999 |
- Palez Piter
- Garsia-Sastre Adol'Fo
- Master Tomas
|
RU2236252C2 |
| PRRS VIRUSES, THEIR INFECTIOUS CLONES, MUTANT FORMS AND METHODS OF APPLICATION |
2006 |
- Faberg Kaj S.
- Khan' Tszjun'
- Lju Gunpin
- Van Jueh
|
RU2427646C2 |
| MUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE ANDMUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE AND METHOD OF ITS PRODUCING |
1993 |
- Bernardus Petrus Khubertus Peters
- Jan Marija Antonius Pol
- Arnol'D Leonard Jozef Gilkens
- Robertus Jakobus Marija Mormann
|
RU2158308C2 |
| VACCINE AGAINST PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS), METHOD OF IMMUNIZATION OF PIG AGAINST PRRS, METHOD OF VACCINE PREPARING, ISOLATED AND PURIFIED STRAIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS |
1996 |
|
RU2192887C2 |
| LABELED SUBUNIT VACCINE AGAINST CLASSICAL SWINE FEVER, METHOD OF ITS PREPARATION AND USE |
2023 |
- Alekseev Konstantin Petrovich
- Zaberezhnyj Aleksej Dmitrievich
- Verkhovskij Oleg Anatolevich
- Musienko Mariya Ivanovna
- Shemelkov Evgenij Vladimirovich
- Yuzhakov Anton Gennadievich
- Aliper Taras Ivanovich
|
RU2808703C1 |
| BVDV VACCINE |
2011 |
- Beer Martin
- Rajmann Ilona
- Kenig Patritsija
|
RU2578943C2 |
