FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology, virology and veterinary. An attenuated recombinant classical swine fever virus (CSFV) is described. Modification is carried out by progressively mutating a portion of the E2 gene of the highly pathogenic strain Brescia. As a result, two to six amino acids on the section 829-837 are replaced with two to six amino acids which are characteristic for the heterologous E2 glycoprotein of the Bovine Viral Diarrhea Virus (BVDV). A classical swine fever vaccine is also obtained based on the obtained attenuated CSFV. The invention can be used in veterinary.
EFFECT: classical swine fever vaccine is obtained.
7 cl, 7 dwg, 4 tbl, 7 ex
| Title |
Year |
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2009 |
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2014 |
|
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| MINUS-CHAIN-CONTAINING ATTENUATED VIRUSES WITH CHANGED ANTAGONISTIC ACTIVITY AS REGARDS FOR INTERFERON FOR APPLYING AS VACCINES AND PHARMACEUTICAL SUBSTANCES |
1999 |
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2006 |
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- Lju Gunpin
- Van Jueh
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| MUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE ANDMUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE AND METHOD OF ITS PRODUCING |
1993 |
- Bernardus Petrus Khubertus Peters
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RU2158308C2 |
| VACCINE COMPOSITION, METHOD OF IMMUNE SYSTEM STIMULATION |
1993 |
- Brajen Robert Merfi
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|
RU2139729C1 |
| BVDV VACCINE |
2011 |
- Beer Martin
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RU2578943C2 |
| VACCINE AGAINST PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS), METHOD OF IMMUNIZATION OF PIG AGAINST PRRS, METHOD OF VACCINE PREPARING, ISOLATED AND PURIFIED STRAIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS |
1996 |
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| MUTANT VIRUS OF BULL DIARRHEA |
2006 |
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