FIELD: biotechnologies.
SUBSTANCE: mutant pestivirus has a mutation in a gene that codes Core protein, resulting in the fact that virus may not express the functional Core protein. At the same time the virus additionally contains one or more mutations in amino acids 2160-2260 of C-end domain of helicase domain NS3 of the specified pestivirus, if the specified pestivirus is CSFV, or amino acids 2169-2269 of the C-end domain of the helicase domain NS3 of the specified pestivirus, if the specified pestivirus is BVD. Such replacements compensate absence of a functional Core protein in the pestivirus.
EFFECT: inventions make it possible to produce attenuated viruses of pestivirus type, which are used to produce vaccines for protection of mammals against an infection caused by pestivirus.
8 cl, 2 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT CLASSICAL SWINE FEVER VIRUS (CSFV), WHICH CONTAINS MODIFIED PROTEIN E2, AND CREATION METHODS OF ABOVE DESCRIBED RECOMBINANT CSFV | 2009 |
|
RU2501854C2 |
| NOVEL VIRULENCE DETERMINANT WITHIN E2 STRUCTURAL GLYCOPROTEIN OF CLASSICAL SWINE FEVER VIRUS | 2007 |
|
RU2451746C2 |
| BVDV VACCINE | 2011 |
|
RU2578943C2 |
| MUTANT VIRUS OF BULL DIARRHEA | 2006 |
|
RU2394594C2 |
| NUCLEOTIDE SEQUENCE OF CLASSIC SWINE FEVER VIRUS (CSFV) (VARIANTS), POLYPEPTIDE CSFV, PESTOVIRAL VACCINE AGAINST CSFV, DIAGNOSTIC SET AND METHOD | 1995 |
|
RU2201451C2 |
| PESTIVIRUSES | 2015 |
|
RU2710041C2 |
| CATTLE DIARRHEA VIRUS WITH MODIFIED E PROTEIN | 2009 |
|
RU2524426C2 |
| IMPROVED DIAGNOSTIC TEST FOR CSFV ANTIBODIES | 2014 |
|
RU2689143C1 |
| MUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE ANDMUTANT GP 50 FOR VECTOR VACCINE PREPARING, VECTOR VACCINE AND METHOD OF ITS PRODUCING | 1993 |
|
RU2158308C2 |
| LABELED SUBUNIT VACCINE AGAINST CLASSICAL SWINE FEVER, METHOD OF ITS PREPARATION AND USE | 2023 |
|
RU2808703C1 |
