FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, in particular to production of monocrystals of biologically active substances, which can be used as precursors for synthesis of pharmaceutical compounds, specifically to a method of producing monocrystals of rhombic form p-acetoluide. Method of producing monocrystals of rhombic form of p-acetoluide is carried out via dissolution of para-acetoluide in a solvent containing ethanol, followed by evaporation of solvent. Initial substance dissolved in a mixture of ethanol and water in ratio of 7:3 to saturation with subsequent evaporation of solvent from layer of a solution which does not exceed 3 mm.
EFFECT: obtaining monocrystalline form of p-acetoluide with a rhombic form.
1 cl, 2 tbl, 2 ex
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