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2 580 763

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(51)

IPC

G01N33/53(2006-01-01)

(21) (22)

Application

2015118295/15, 2015-05-15

(24)

Start date

2015-05-15

(22)

Actual filing date

2015-05-15

(45)

Published

2016-04-10

(72)

Inventor

Lutsenko Mikhail TimofeevichAndrievskaja I.A.Dovzhikova Inna Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Nauchnoe Uchrezhdenie Nauchnyj Tsentr Fiziologii Patologii Dykhanija"

METHOD FOR DETERMINATION OF REDUCTION OF OESTRIOL IN PLACENTAL HOMOGENATE IN CONNECTION WITH INCREASE IN SYNTHESIS OF PHOSPHODIESTERASE IN AGGRAVATED CYTOMEGALOVIRAL INFECTION IN THIRD TRIMESTER OF GESTATION Russian patent published in 2016 - IPC G01N33/53

Abstract RU 2580763 C1

FIELD: medicine.

SUBSTANCE: method comprises measuring in peripheral blood antibody titre to CMV and phosphodiesterase and adenylate cyclase activity in membrane syncytiotrophoblast and estriol content in homogenate of placenta, and titre of antibodies to CMV 1:1600, reduction in membrane adenylate cyclase to syncytiotrophoblast 10.0±0.2 conventional units, increased activity in membrane of syncytiotrophoblast phosphodiesterase to 18.00±0.31 conventional units and reducing content of estriol in placenta homogenate to 177.50±7.80 nmol/l is a threat to formation of placental insufficiency.

EFFECT: invention can be used to diagnose formation of placental insufficiency at an exacerbation of cytomegalovirus infection in third trimester of gestation.

1 cl, 2 dwg

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RU 2 580 763 C1

Authors

Lutsenko Mikhail Timofeevich

Andrievskaja I.A.

Dovzhikova Inna Viktorovna

Dates

2016-04-10—Published

2015-05-15—Filed