FIELD: chemistry.
SUBSTANCE: invention relates to the novel derivatives of 2-arylbenzofurane-7-formamide of general formula where R1 and R2 each independently on each other represent hydrogen, linear or branched C1-C4-alkyl, C3-C4-cycloalkyl or substituted 5- or 6-membered heterocycle, containing oxygen or nitrogen; or R1 and R2 together with N form a non-substituted or substituted saturated 5- or 6-membered heterocycle, containing at least one heteroatom, where the heteroatom represents O, N and S, the substituent represents methyl on N; R3 represents a hydrogen atom or a chlorine atom; R4 represents a hydrogen atom or a fluorine atom; X represents CH, CF or N; and Y represents CH, CF or N, or its pharmacologically or physiologically acceptable salt, as well as to a method for obtaining thereof and application in obtaining anti-tumour and anti-inflammation medications.
EFFECT: increased efficiency of the compound application.
8 cl, 5 tbl, 24 ex
Title | Year | Author | Number |
---|---|---|---|
DIHYDRONAPHTHYRIDINES AND RELATED COMPOUNDS SUITABLE AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | 2018 |
|
RU2804468C2 |
CALPAIN MODULATORS AND THEIR THERAPEUTIC USE | 2017 |
|
RU2773288C2 |
INFLUENZA VIRUS REPLICATION INHIBITORS, METHODS OF APPLICATION AND USING | 2016 |
|
RU2737190C2 |
ARGINASE INHIBITORS AND THERAPEUTIC USE THEREOF | 2011 |
|
RU2586219C2 |
PHTHALAZINE KETONE DERIVATIVE, METHOD OF OBTAINING THEREOF AND PHARMACEUTICAL APPLICATION | 2011 |
|
RU2564527C2 |
INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES | 2014 |
|
RU2666532C2 |
ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN MEDICINE | 2017 |
|
RU2729069C1 |
HETEROCYCLIC COMPOUND USED AS A FGFR INHIBITOR | 2017 |
|
RU2742485C2 |
2-CYANOPYRIMIDINE-4-YL CARBAMATE, OR A UREA DERIVATIVE, OR ITS SALT AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | 2019 |
|
RU2788740C2 |
PYRROLIDINE AND PIPERIDINE COMPOUNDS | 2020 |
|
RU2803455C1 |
Authors
Dates
2016-05-10—Published
2013-01-14—Filed