FIELD: pharmaceutics.
SUBSTANCE: invention relates to derivatives of diarylpyridazinone, which block potassium Kv channels (in particular, Kv1.5, Kv4.3 and Kv11.1 channels). Compounds have general formula (I), where R1 and R2 simultaneously or independently represent one or more groups selected from halogen, such as F, Br, Cl, linear or branched C1-C4 alkyls, hydroxy, linear or branched C1-C4 alkoxy, phenylsulfonamide, where phenyl can be substituted with linear or branched C1-C4 alkyl or nitrile. Invention includes different enantiomers of compounds of formula (I) and their mixtures in any proportions and their pharmaceutically acceptable salts. Invention also relates to method of producing compounds of formula (I) and pharmaceutical composition containing them.
EFFECT: treatment and/or prevention of atrial fibrillation and/or ventricular cardiac arrhythmia, cancer or chronic inflammation.
10 cl, 1 tbl, 11 ex
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