METHOD OF PRODUCING pan-CDK INHIBITORS OF FORMULA (I), AND INTERMEDIATE COMPOUNDS FOR PRODUCTION THEREOF Russian patent published in 2016 - IPC C07D239/47 C07C381/10 C07C69/76 C07C309/29 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method for producing pan-CDK inhibitors (cyclin-dependent kinase) of general formula (I). Compounds of general formula (I) , where R⁴ is (C₁-C₆)-alkyl group or (C₃-C₇)-cycloalkyl ring, are obtained by connection of the previously obtained compounds (I-7-A) to (I-4-R) in the presence of benzenesulphonic acid as a catalyst, with resulting salts of benzenesulphonic acid (BSA) protected phenyl amine pyrimidine of formula (I-8-R-BSA) , with removal of protective groups in the salts of formula (I-8-R-BSA) by hydrogenation in the presence of palladium on active carbon in methanol and treatment with potassium carbonate in methanol to obtain compounds of formula (I) . Invention also relates to novel intermediate compounds of structural formulae (I-8-A-R-BSA) and (I-11-A-R-D-Tol-Tart). , .

EFFECT: method simplifies conditions for production of intermediate and end products, which allows its use on an industrial scale.

7 cl, 2 tbl