FIELD: chemistry.
SUBSTANCE: present invention relates to method of producing hydrochloride salt (HCl) of compound of formula (I), wherein Y1 and Y2 independently denote F or Cl, preferably F, wherein said compound of formula (I) contains a cis-isomer and trans-isomer, which involves (1) using compound of formula (I), contained in first suitable solvent; and (2) treating compound of formula (I) contained in first suitable solvent, with help of HCl, contained in second suitable solvent to obtain HCl salt of compound of formula (I).
EFFECT: invention also relates to crystalline hydrochloride salt (HCl) containing cis-isomer (II) and trans-isomer (III), use of said salt for preparing fungicide and to use of method for cleaning of mixture of diastereomers cis-isomer (II) and trans-isomer (III).
32 cl, 1 dwg, 6 ex
(I) 
(II) 
(III)
| Title | Year | Author | Number |
|---|---|---|---|
| OBTAINING INTERMEDIATE PRODUCTS FOR SYNTHESIS OF POSACONAZOLE | 2011 |
|
RU2580318C2 |
| METHOD OF PRODUCING CHIRAL TRIAZOLONES | 2011 |
|
RU2585760C2 |
| METHOD OF PREPARING CIS-NUCLEOSIDE ANALOGS, THEIR SALTS AND ESTERS | 1994 |
|
RU2139870C1 |
| HYDROCARBON GEL-BASED PRODRUGS | 2013 |
|
RU2647729C2 |
| METHOD FOR CHIRAL RESOLUTION OF 2,4-DISUBSTITUTED 1,3-OXATHIOLANES | 2008 |
|
RU2494098C2 |
| INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF TRANS-5-CHLORO-2-METHYL-2,3,3a,12b-TETRAHYDRO-1H-DIBENZ[2,3:6,7]-OXEPINO[4,5-c]PYRROLE | 2006 |
|
RU2397164C2 |
| A-EXO-AZASPIRO-INHIBITORS OF THE MENIN-MLL INTERACTION | 2018 |
|
RU2795096C2 |
| IMIDAZOLE DERIVATIVES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF AND METHOD FOR TREATMENT BY THEIR USING | 2001 |
|
RU2265598C2 |
| METHOD FOR INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH | 2001 |
|
RU2269339C2 |
| VEGF NEUTRALISING PRODRUGS FOR THE TREATMENT OF OCULAR CONDITIONS | 2013 |
|
RU2673881C2 |
