METHOD OF PRODUCING CHIRAL TRIAZOLONES Russian patent published in 2016 - IPC C07D405/14 A61K31/496 A61P31/10 

FIELD: chemistry.

SUBSTANCE: invention relates to method of producing compound of formula (IVb), involving (1.1) using compound of formula (Ia) or salts thereof (Ia) (1.2) using phosgene derivative of formula (IIb) (IIb), wherein Y₁N-and Y₂N-denote identical or different optionally substituted nitrogen-containing heterocyclic fragments, preferably selected from group comprising imidazolyl and benzimidazolyl; (1.3) using compound of formula (III) or salts thereof (III), in which R₁ denotes ethyl, and in which R denotes h; (2) mixing and introduction into reaction of compounds of formulae (Ia), (IIb) and (III) in solvent in any order to obtain reaction mixture containing Chiral compound of formula (IVb) (IVb). Invention also relates to chiral compound of formula (IVb), to optionally crystalline chiral compound of formula (IVb) and to compound of formula (IIc) (IIc) to obtain compound of formula (IVb) or formula (IVd).

EFFECT: technical result is new non-toxic method of producing compound of formula (IVb).

29 cl, 5 dwg, 6 ex