ACYLBENZENE DERIVATIVES Russian patent published in 2016 - IPC C07D271/06 A61K31/4245 A61P3/04 A61P3/10 

FIELD: medicine.

SUBSTANCE: invention relates to a compound of general formula (I), and pharmaceutically acceptable salts thereof where R¹ represents a hydroxy C1-C6 alkyl group or hydroxy C3-C6 cycloalkyl group, each of which can be substituted with 1-3 substitutes selected from a subgroup of substitutes α, substitutes subgroup α is a group consisting of hydroxyl groups and carbamoyl group, R² is a methyl group or ethyl group, R³ represents C1-C6 alkyl group or C3-C6 cycloalkyl group each of which can be substituted with 1-3 halogen atoms, and R⁴ is a halogen atom. Invention also relates to individual compounds; a pharmaceutical composition possessing hypoglycemic action and/or protective action on βcells or pancreas, containing as an active ingredient, compound, use of compounds for preparing pharmaceutical composition; a method of treating type 1 diabetes or diabetes type 2; and to a method for protection of β-cells or pancreas.

EFFECT: obtaining novel compounds of general formula (I), having hypoglycemic action and/or protective action on β-cells or pancreas.

35 cl, 56 ex