FIELD: medicine.
SUBSTANCE: group inventions relates to prophylaxis and/or treatment of pain associated with bone cancer. Disclosed is use of a sigma-ligand, which is a 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine, a salt or stereoisomer thereof for prevention and/or treatment of pain associated with bone cancer; use of same compound for production of a medicament for same purpose, a method of treating pain associated with bone cancer and use of a combination of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine, or a salt or stereoisomer thereof and an opiate or opioid compound for prevention and/or treatment of pain associated with bone cancer.
EFFECT: technical result consists in implementing claimed devices and synergistically analgesic effect of morphine on cancer pain model.
7 cl, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2569055C2 |
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|
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|
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|
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|
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|
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|
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|
RU2519060C2 |
| 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHBITORS | 2007 |
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|
RU2582338C2 |
