FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and can be used for treating acquired disorder resistant to methotrexate in a subject. For this purpose, said subject suffering from acquired disorder resistant to methotrexate is administered a pharmaceutically effective amount of a composition which contains 10-propargyl-10-deazaaminopterin or pharmaceutically acceptable salts thereof. Also provided is a method of treating a subject in need of treatment for acquired neoplasia.
EFFECT: group of inventions provides effective treatment of acquired disorders resistant to methotrexate in a subject, such as: neoplasia, rheumatoid arthritis.
12 cl, 20 dwg, 6 tbl, 2 ex
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