FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns a pharmaceutical microspherical composition containing rotigotine or pharmaceutically acceptable salt thereof; at least one polylactide-glycolide (PLGlA) with molecular weight of 5,000-100,000 Da and polymerisation ratio lactide:glycolide 95:5 to 5:95; and at least one fatty acid having 8-24 carbon atoms, where content of rotigotine or pharmaceutically acceptable salt thereof is 20-40 %, PLGlA is 45-79 %, and at least one fatty acid is 1-15 wt% relative to total weight of composition. Group of inventions also relates a method of treating Parkinson's disease using said compositions.
EFFECT: group of inventions provides rotigotine composition, which significantly reduces explosive release of preparation.
23 cl, 28 ex, 12 tbl, 38 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| RISPERIDONE SUSTAINED RELEASE MICROSPHERE COMPOSITION | 2012 |
|
RU2586306C2 |
| THERMOFUSIBLE TTS FOR APPLYING ROTIGOTIN | 2003 |
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| DOSED FORMS OF ANESTHETICS FOR ANESTHESIA WITH LONG LIBERATION | 2003 |
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| METHODS AND COMPOSITIONS CONTAINING CLONIDINE, APPLICABLE FOR TREATING POSTOPERATIVE PAIN | 2009 |
|
RU2510263C2 |
| DEVICE FOR TRANSDERMAL INTRODUCTION OF ROTIGOTINE IN ORGANISM IN FORM OF BASE | 2003 |
|
RU2340339C2 |
