PEPTIDE COMPOUND, USEFUL FOR INHIBITING FORMATION OF AMYLOID PLAQUES Russian patent published in 2016 - IPC C07K5/10 A61K38/07 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to peptide compound R^a-R¹-R²-R³-R⁴-R^b (I) or R^a-R⁴-R³-R²-R¹-R^b (II), where R^a is N-end primary amine group of amino acid R¹ or R⁴, or free, or substituted with an amino protective group, R^b is a hydroxyl group of C-end carboxyl group of amino acid R¹ or R⁴, or free, or substituted with hydroxy protective group, and R¹-R²-R³-R⁴ or R⁴-R³-R²-R¹ represent HADD, KADD, DDAK, RADD, DDAR, KAED, NEAR, 5, DEAR, HADE, EDAH, KADE, EDAK, HAMBURG, EDAR, HAEE, EEAH, KAEE, EEAK, WEEE and EEAR. Present invention also relates to use of said useful peptide compounds, in particular, for binding with β-amyloid peptides and inhibiting polymerisation in form of amyloid plaques.

EFFECT: compounds can be used as a drug or for preparing or determining preparations for treating neurodegenerative diseases, particularly Alzheimer's disease.

21 cl, 9 dwg, 2 tbl, 4 ex