FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Described is recombinant antibody, fragment thereof, neutralising human VEGF, containing variable heavy chain region (VH), where VH contains CDRH1, CDRH2 and CDRH3 sequence SEQ ID NO:8, SEQ ID NO:20 and SEQ ID NO:32 respectively, and light chain variable region (VL), where VL contains CDRL1, CDRL2 and CDRL3 sequence SEQ ID NO:43, SEQ ID NO:55 and SEQ ID NO:66 respectively, and where variable heavy chain region contains amino acid sequence SEQ ID NO:164 and variable light chain domain contains amino acid sequence SEQ ID NO:87.
EFFECT: presented pharmaceutical compositions for treating VEGF-mediated diseases and methods of treating VEGF-mediated disease.
10 cl, 15 dwg, 12 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VEGF INHIBITING STABLE AND SOLUBLE ANTIBODIES | 2009 |
|
RU2531523C9 |
| STABLE AND SOLUBLE VEGF INHIBITING ANTIBODIES | 2018 |
|
RU2696972C1 |
| STABLE AND SOLUBLE ANTIBODIES INHIBITING VEGF | 2016 |
|
RU2648152C2 |
| STABLE AND SOLUBLE ANTIBODIES INHIBITING VEGF | 2019 |
|
RU2747735C2 |
| HUMANIZING RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK | 2018 |
|
RU2696202C1 |
| HUMANIZATION OF RABBIT ANTIBODIES USING THE UNIVERSAL ANTIBODY FRAME | 2014 |
|
RU2652907C2 |
| HUMANISATION OF RABBIT ANTIBODIES USING UNIVERSAL ANTIBODY SCAFFOLD | 2009 |
|
RU2567006C2 |
| STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα | 2018 |
|
RU2678120C1 |
| STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα | 2009 |
|
RU2653753C1 |
| STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα | 2009 |
|
RU2567100C2 |
