HUMANIZING RABBIT ANTIBODIES USING A UNIVERSAL ANTIBODY FRAMEWORK Russian patent published in 2019 - IPC C07K16/24 C07K16/22 C12N15/13 A61K39/395 

FIELD: biotechnology.

SUBSTANCE: described is an immuno-binding molecule containing: CDR1, CDR2 and CDR3 of a light chain from a donor immunobinding molecule of a hare-like and CDR1, CDR2 and CDR3 of a heavy chain from a donor immunobinding molecule of a hare-like; a human light chain variable region framework and a human heavy chain variable region framework which is at least 85 % identical to the sequence SEQ ID NO: 4 and contains threonine (T) in position 24 (numbering AHo). Also disclosed is a method for humanizing said immunobinding molecule.

EFFECT: claimed molecule is suitable for some diagnostic and therapeutic applications.

19 cl, 6 dwg, 9 tbl, 5 ex