METHOD OF PRODUCING CHIRAL HYDRAZIDES Russian patent published in 2016 - IPC C07C243/28 C07C251/76 C07D405/14 C07F7/18 A61K31/496 A61P31/10 

FIELD: chemistry.

SUBSTANCE: invention relates to methods of producing chiral compounds, particularly to method of producing chiral compound of formula (II). Method involves reaction of chiral compound of formula (I) with H₂N-NH-CHO in solvent to obtain compound of formula (II). In formulae (I) and (II) Y denotes substituted or unsubstituted aryl fragment, wherein substituted aryl fragment contains 1, 2 or 3 substitutes, which are selected from group comprising halogen, alkyl and C₁-C₆alkoxy group. Invention also relates to methods of producing chiral compounds of formulae (III)-(V) using method of producing chiral compound of formula (II), chiral compounds of formulae (II)-(V) and use thereof to obtain fungicidal agent, preferably of posaconazole.

EFFECT: in formulae (III)-(V) Y has value specified for compounds of formulae (I) and (II); R_aa, R_bb and R_cc can be identical or different and denote alkyl or aryl residue; R₁ denotes an alkyl residue.

31 cl, 2 dwg, 3 ex