FIELD: chemistry.
SUBSTANCE: invention relates to a method of converting optical configuration of optically pure or optically enriched (S)-(+)- (I) and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepin-5-carboxamide (II) using a nucleophilic reagent based on carboxylic acid in the presence of tri-substituted phosphine and di-substituted azodicarboxylate in essentially inert solvent. The invention also relates to a method of producing compounds of formulae 
, (S)-(-)- and (R)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz/b,f/azepin-5-carboxamide.
EFFECT: proposed method is distinguished by high purity and output end products.
20 cl, 5 ex
| Title |
Year |
Author |
Number |
| METHOD OF RACEMATION OF (S)-(+) AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DEBENZ(b,f)AZEPIN-5-CARBOXAMIDE AND THEIR OPTICALLY ENRICHED MIXTURES |
2004 |
- Lermont Dehvid Aleksander
|
RU2345986C2 |
| METHODS FOR PREPARING OPTICALLY PURE (S)-(+)- AND/OR (R)-(-)-ISOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE, THEIR CORRESPONDING 10-ACETOXY-DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS |
2002 |
- Lermont Dehvid Aleksander
|
RU2318813C2 |
| SUBSTITUTED DIHYDRODIBENZO[B,F]AZEPINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIEPILEPTIC ACTIVITY |
1996 |
- Zhan Benes
- Patrisio Manuehl V'Ejru Arauzho Suarish Da Silva
|
RU2168502C2 |
| METHOD FOR PREPARING 10,11-DIHYDRO-1-HYDROXY-5H-DIBENZ[b,f]AXEPINE-5-CARBOXAMIDE AND 10,11-DIHYDRO-10-OXO-5H-DIBENZ[b,f]AZEPINE-5-CARBOXAMIDE |
2002 |
- Lermont Dehvid Aleksander
|
RU2311411C2 |
| ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE |
2006 |
- Lermont Dehvid Aleksander
- Grasa Gabr'Ela Aleksandra
- Tsanotti-Dzheroza Antonio
|
RU2439060C2 |
| METHOD FOR PREPARING 10,11-DIHYDRO-10-OXO-5N-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE |
2007 |
- Lermont Dehvid Aleksander
|
RU2449992C2 |
| METHOD OF PRODUCING 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/b, f/AZEPINE-5-CARBOXAMIDE |
2006 |
- Lermont Dehvid Aleksander
- Vajngertner Gjunter
- Kremer Mattias
|
RU2418789C2 |
| NEW DERIVATIVES OF 10,11-DIHYDRO-10-OXO-5H-DIBENZO- -[B,F]AZEPINE-5- CARBOXAMIDE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF CONVULSANT STATES |
1997 |
- Benesh Jan
- Soares Da Silva Patrisio Manuehl V'Ejra Arauzho
- Learmont David Aleksandr
|
RU2187503C2 |
| APPLICATION OF 10-HYDROXY-10,11-DIHYDROCARBAMAZEPINE DERIVATIVES FOR TREATMENT OF AFFECTIVE DISORDERS |
2004 |
- Martenii Ferents
- Shmutts Markus
- Tsekhner Shtefani
|
RU2367440C2 |
| N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND THEIR ESTERS, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF NEUROGENOUS PAIN, INFLAMMATION AND BLOOD GLUCOSE LEVEL IN PATIENT |
1996 |
- Florentsio Zaragossa Dervall'
- Knud Ehrik Andersen
- Peter Madsen
- Tine Krokh Jorgensen
- Rol'F Khol'Vaj
- Khenrik Sune Andersen
- Svenn Treppendal'
- Uffe Bang Ol'Sen
- Zdenek Polivka
- Aleksandra Silgankova
- Karel Sindelar
|
RU2244713C2 |
