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2 589 053

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/5386(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014147863/04, 2013-04-23

(24)

Start date

2013-04-23

(22)

Actual filing date

2013-04-23

(45)

Published

2016-07-10

(72)

Inventor

Yan ChunkhaoMen LinkhuaChen YankhunVan SyanTan TsunLi TszyapenDin TszyanChen I

(73)

Holder

Shankhaj Instityut Of Matiria Medika, Chajniz Ekedemi Of SajensizShankhaj Grin Velli Farmasyutikal Ko., Ltd.

PYRROLO[2,1-f][1,2,4]TRIAZINE COMPOUND, METHOD FOR PRODUCTION AND USE THEREOF Russian patent published in 2016 - IPC C07D487/04 A61K31/5377 A61K31/5386 A61P35/00

Abstract RU 2589053 C1

FIELD: chemistry.

SUBSTANCE: invention relates to pyrrolo[2,1-f][1,2,4]triazine compound of general formula I, its isomer, pharmaceutically acceptable salt, ester or hydrate. Compound of general formula I possess properties of PI3K kinase activity. In general formula I X is CH or N; R₁ is -NR₅R₆; R₂ is ; R₃ is -NH₂, -NHC(O)NHR₁₁, -NHC(O)OR₁₁, -NHC(O)R₁₁, -CH₂OH, -CH₂S(O)₂R₁₂ or -CH₂NHS(O)₂R₁₂; R₄ is H or CF₃. Invention also relates to a method of producing pyrrolo[2,1-f][1,2,4]triazine compounds of general formula I and use thereof in preparing drugs for treating a disease associated with phosphatidylinositol 3-kinase and inhibitor of rapamycin target protein.

EFFECT: technical result is obtaining novel pyrrolo[2,1-f][1,2,4] triazine compound of general formula I, having PI3K kinase activity inhibitor properties.

11 cl, 2 dwg, 5 tbl, 39 ex

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RU 2 589 053 C1

Authors

Yan Chunkhao

Men Linkhua

Chen Yankhun

Van Syan

Tan Tsun

Li Tszyapen

Din Tszyan

Chen I

Dates

2016-07-10—Published

2013-04-23—Filed