FIELD: medicine.
SUBSTANCE: presented group of inventions relates to non-viral RNA delivery for immunisation. Disclosed is liposome for RNA in vivo delivery into cell of vertebrate animal with lipid bilayer containing lipid, having tertiary amine and value of pKa from 5.0 to 6.8, which encapsulates water core including RNA coding immunogen. Invention also discloses pharmaceutical composition containing said liposome, method of producing liposomes, method of inducing protective immune response in vertebrate animal and application of liposomes or pharmaceutical composition for inducing protective immune response in vertebrate animal.
EFFECT: presented group of inventions provides effective in vivo delivery of RNA for induction of protective immune response in vertebrate animal.
15 cl, 21 dwg, 18 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LIPIDS SUITABLE FOR LIPOSOMAL DELIVERY OF RNA ENCODING PROTEIN | 2011 |
|
RU2577983C2 |
| SMALL LIPOSOMES FOR DELIVERY OF IMMUNOGEN CODING RNA | 2011 |
|
RU2671482C2 |
| PEGYLATED LIPOSOMES FOR IMMUNOUGEN-CODING RNA DELIVERY | 2012 |
|
RU2628705C2 |
| ANTIGEN DELIVERY PLATFORMS | 2011 |
|
RU2597974C2 |
| CATIONIC OIL-IN-WATER EMULSIONS | 2012 |
|
RU2649133C2 |
| RSV F PROTEIN COMPOSITION AND METHODS FOR PRODUCTION THEREOF | 2010 |
|
RU2585227C2 |
| CATIONIC EMULSIONS "OIL-IN-WATER" | 2011 |
|
RU2625546C2 |
| TRANS-REPLICATING RNA | 2017 |
|
RU2752580C2 |
| NANOSTRUCTURED LIPID CARRIERS AND STABLE EMULSIONS AND APPLICATIONS THEREOF | 2018 |
|
RU2816240C2 |
| PLASMID pVAX-RBD DNA MATRIX OF mRNA-RBD MOLECULES, OBTAINED USING THE pVAX - RBD DNA MATRIX, PROVIDING THE SYNTHESIS AND SECRETION OF THE RBD PROTEIN SARS-CoV 2 IN MAMMALIAN CELLS AND A COMPLEX IN THE FORM OF NANOPARTICLES CONTAINING mRNA-RBD MOLECULES THAT INDUCE SARS-CoV-SPECIFIC ANTIBODIES WITH VIRAL NEUTRALIZING ACTIVITY | 2021 |
|
RU2754230C1 |
