FIELD: medicine.
SUBSTANCE: proposed group of inventions relates to medicine. Stable oil-in-water emulsion is provided to deliver the RNA molecule to the cell, wherein said emulsion comprises an oil and a cationic lipid DOTAP. Methods for preparing an emulsion and a composition are provided. Composition for delivering an RNA molecule to a cell and its use in a method for generating an immune response are proposed.
EFFECT: proposed group of inventions ensures efficient delivery of negatively charged molecules and production of vaccines based on nucleic acids.
19 cl, 4 dwg, 15 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CATIONIC EMULSIONS "OIL-IN-WATER" | 2011 |
|
RU2625546C2 |
| EMULSIONS OF “OIL-IN-WATER” TYPE, WHICH CONTAIN NUCLEIC ACIDS | 2012 |
|
RU2606846C2 |
| LIPOSOMES WITH LIPIDS, HAVING PREFERRED VALUE OF PKA FOR RNA DELIVERY | 2011 |
|
RU2589503C2 |
| NANOSTRUCTURED LIPID CARRIERS AND STABLE EMULSIONS AND APPLICATIONS THEREOF | 2018 |
|
RU2816240C2 |
| ANTIGEN DELIVERY PLATFORMS | 2011 |
|
RU2597974C2 |
| SMALL LIPOSOMES FOR DELIVERY OF IMMUNOGEN CODING RNA | 2011 |
|
RU2671482C2 |
| PEGYLATED LIPOSOMES FOR IMMUNOUGEN-CODING RNA DELIVERY | 2012 |
|
RU2628705C2 |
| NANO-ALUMINUM-PARTICLES CONTAINING SIZE-REGULATING AGENT | 2017 |
|
RU2753874C2 |
| RSV F PROTEIN COMPOSITION AND METHODS FOR PRODUCTION THEREOF | 2010 |
|
RU2585227C2 |
| LIPIDS SUITABLE FOR LIPOSOMAL DELIVERY OF RNA ENCODING PROTEIN | 2011 |
|
RU2577983C2 |
