FIELD: medicine.
SUBSTANCE: composition comprising a self-replicating RNA molecule encoding an antigen in combination with a cationic oil-in-water emulsion particle is provided, wherein the particle contains an oil core and a cationic lipid and wherein the average particle diameter of the emulsion particles is from about 80 to 180 nm. Method for preparing the above composition, methods for eliciting an immune response in an individual, and using a composition for eliciting an immune response are provided.
EFFECT: stable compositions suitable for the delivery of RNA molecules encoding an antigen into cells and the preparation of vaccines based on such molecules.
35 cl, 14 dwg, 31 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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