METHOD OF PRODUCING NONAPEPTIDES Russian patent published in 2016 - IPC C07K1/04 C07K7/06 A61K38/08 A61P7/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a solid-phase method of producing nonapeptides of the following formula I-III: $$R-Ar{g}^1-Ly{s}^2-Ly{s}^3-Ty{r}^4-Ly{s}^5-Ty{r}^6-Ar{g}^7-Xa{a}^8-Ly{s}^9-N{H}_2,$$ where R=H, Xaa=L-Arg (I); R=Me, Xaa=L-Arg (II); R=H, Xaa=D-Axg (III). Nonapeptides synthesis as per formula I-III is carried out by serial growth of the peptide chain, starting with the C-terminal amino acid covalently bound with the polymer matrix using N^α-protected derivatives of arginine, for blocking the guanidine function of which protonating is used. For the guanidine function protonation 1-hydroxybenzotriazole, hexafluorophosphate or tetrafluoroborate is used. Obtained nonapeptidilpolymer is processed with an unblocking agent for removing the protective groups and the polymeric matrix and in 1 stage the end product is given out by means of HELC.

EFFECT: method increases the output of end products, simplifies and lowers the cost of their production process.

4 cl, 5 dwg, 5 tbl, 3 ex