METHOD OF IMMUNE-ENZYME ASSAY FOR DETECTING β-ADRENORECEPTOR AUTOIMMUNE ANTIBODIES IN HUMAN BLOOD PLASMA AND SERUM Russian patent published in 2012 - IPC G01N33/53 G01N33/543 C07K14/705 

Abstract RU 2452964 C1

FIELD: medicine.

SUBSTANCE: invention discloses a method of solid-phase immune-enzyme assay wherein as an antigen, an equimolar mixture of synthetic peptides is immobilised on plastic with the mixture containing: nonapeptide (position 125-133), tridecapeptide (position 208-218) of an amino acid sequence of a human β1 adrenoreceptor molecule and a chimeric construct of the same peptides jointed by a disulphide bond. The presented method shows substantially greater sensitivity in detecting the presence of β1-adrenoreceptor autoimmune antibodies in blood plasma and serum in the patients with dilatation cardiomyopathy.

EFFECT: invention is also applicable for diagnosing the patients with various cardiovascular diseases.

1 dwg, 4 ex

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RU 2 452 964 C1

Authors

Afanas'Eva Ol'Ga Il'Inichna

Klesareva Elena Aleksandrovna

Sidorova Marija Vladimirovna

Pal'Keeva Marina Evgen'Evna

Bespalova Zhanna Dmitrievna

Levashov Pavel Andreevich

Pokrovskij Sergej Nikolaevich

Kipor Svetlana Gennadievna

Dates

2012-06-10Published

2011-04-15Filed