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IPC

A61K39/00(2006-01-01)

G01N33/531(2006-01-01)

C07K14/705(2006-01-01)

(21) (22)

Application

2007146059/15, 2007-12-13

(24)

Start date

2007-12-13

(22)

Actual filing date

2007-12-13

(45)

Published

2009-05-27

(72)

Inventor

Pokrovskij Sergej NikolaevichAfanas'Eva Ol'Ga Il'InichnaLevashov Pavel AndreevichDmitrieva Oksana AleksandrovnaEfremov Evgenij Evgen'EvichBespalova Zhanna DmitrievnaSidorova Marija VladimirovnaPal'Keeva Marina Evgen'Evna

(73)

Holder

Federal'Noe Gosudarstvennoe Uchrezhdenie Kardiologicheskij Nauchno-Proizvodstvennyj Kompleks Rosmedtekhnologij" Rosmedtekhnologij")

SYNTHETIC ANTIGEN ABILITY TO BIND β-ADRENORECEPTOR AUTOANTIBODIES Russian patent published in 2009 - IPC A61K39/00 G01N33/531 C07K14/705

Abstract RU 2356576 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to immunology. β₁-adrenoreceptor autoantibodies in human blood plasma/serum are bonded with a synthetic antigen containing nonapeptide (125-133) and tridecapeptide (208-218) of human β₁-adrenoreceptor sequences interbinded with disulfide bridge. The antigen is characterised with higher affinity as compared to applied 1st and 2nd loop β₁-adrenoreceptor sequences.

EFFECT: invention can be used for diagnostics and treatment of the patients suffering from dilated cardiomyopathy.

3 ex, 1 tbl, 1 dwg

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RU 2 356 576 C1

Authors

Pokrovskij Sergej Nikolaevich

Afanas'Eva Ol'Ga Il'Inichna

Levashov Pavel Andreevich

Dmitrieva Oksana Aleksandrovna

Efremov Evgenij Evgen'Evich

Bespalova Zhanna Dmitrievna

Sidorova Marija Vladimirovna

Pal'Keeva Marina Evgen'Evna

Dates

2009-05-27—Published

2007-12-13—Filed