METHOD OF PRODUCING CYCLIC ESTERS CONTAINING UNSATURATED FUNCTIONAL GROUPS, AND POLYESTERS PRODUCED THEREFROM Russian patent published in 2016 - IPC C07D319/12 

FIELD: chemistry.

SUBSTANCE: invention relates to method of producing cyclic esters containing unsaturated functional groups of formula I, where each x is same and is integer ranging from 0 to 12; where each R^1a and each R^1b when are present, independently hydrogen, hydroxy, amino, thio, halogen, substituted or unsubstituted C₁-C₆alkilom, substituted or unsubstituted C₁-C₆alkoksi, substituted or unsubstituted C₁-C₆alkiltio, substituted or unsubstituted C₁-C₆alkilaminom, or substituted or unsubstituted C₁-C₆gidroksialkilom; provided that each R^1a is the same and each R^1b is the same; where R² is hydrogen, hydroxy, amino, thio, halogen, substituted or unsubstituted C₁-C₆alkilom, substituted or unsubstituted C₁-C₆alkoksi, substituted or unsubstituted C₁-C₆alkiltio, substituted or unsubstituted C₁-C₆alkilaminom, or substituted or unsubstituted C₁-C₆gidroksialkilom; and where is in some cases bond; which involves heating of liquid reaction medium containing oligomeric α-hydroxyacid of formula II or its salt, where n is integer from 2 to 30 and where x, R^1a, R^1b, R² and is as defined above, at temperature of approximately 150 °C to approximately 300 °C to form cyclic ester, along with removal of liquid reaction medium composition containing cyclic ester.

EFFECT: these compounds can be used for preparing biocompatible and biodegradable polymers, which can be used as carriers for drug delivery.

16 cl, 2 ex