CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILIC-ACTIVATED POLYOXAZOLINE Russian patent published in 2016 - IPC C08G73/02 C08L79/02 A61K47/48 A61L27/18 A61L31/06 A61L31/14 

FIELD: chemistry.

SUBSTANCE: invention relates to biocompatible with glue for fabric, covalently cross-linked polymer, a kit for producing cross-linked polymer, as well as to a medical product and biocompatible medical article. Kit for preparing biocompatible cross-linked polymer contains electrophilically activated polyoxazoline (EL-POX) and nucleophilic cross-linking agent, which are not identical. Polymer EL-POX has molecular weight of at least 5,000 g/mol, and has m electrophilic groups. Nucleophilic cross-linking agent contains n nucleophilic groups. Wherein m electrophilic groups are capable of reacting with n nucleophilic groups to form covalent bonds, where m ≥ 2, n ≥ 2, and m + n ≥ 5. At least one of m electrophilic groups is a lateral electrophilic group. Number of electrophilic groups m can be at least 13. Polymer EL-POX contains excess amount of electrophilic groups in relation to number of nucleophilic groups. Covalently cross-linked polymer contains free electrophilic groups, which are not coming into a reaction with nucleophilic groups of cross-linking agent. Biocompatible medical product contains at least 1 wt% of said covalently cross-linked polymer and represents an implant sealant for fabric, an adhesive tape for fabric, an adhesive film for fabric material for surgical suture, stent with polymer coating, haemostatic (porous) material. Adhesive tape and adhesive film include glue for fabric.

EFFECT: invention enables to obtain biodegradable polymer, having excellent film-forming capacity, and good characteristics of implant and/or sealant.

15 cl, 8 ex