FIELD: chemistry.
SUBSTANCE: method involves activation of hyaluronic acid using a cross-linking agent and an auxiliary cross-linking agent. The activated hyaluronic acid then reacts with a nucleophilic cross-linking agent. The pH of the reaction medium ranges from 8 to 12. The nucleophilic cross-linking agent contains at least 50 wt % oligopeptide or polypeptide. Further, pH of the reaction medium is regulated to 5-7 and cross-linked hyaluronic acid is precipitated in the organic solvent. The invention also relates to use of the cross-linked hyaluronic acid obtained using this method in plastic surgery to make implants and to a hedrogel containing said cross-linked hyaluronic acid in a buffer aqueous solvent.
EFFECT: invention enables to obtain cross-linked hyaluronic acid in dry form, having high resistance to decomposition factors such as temperature, free radicals and enzymes.
18 cl, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SKIN FILLERS COMPOSITIONS | 2012 |
|
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| COMPOSITION OF SKIN FILLER AND TREATMENT METHOD | 2012 |
|
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| DERMAL INJECTABLE STERILE COMPOSITION | 2013 |
|
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| STABILIZED HYALURONIC ACID | 2019 |
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| HYDROGEL CONTAINING HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AS SUBSTRATE, AND ITS USE | 2018 |
|
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| METHOD FOR MANUFACTURING FORMATED PRODUCT FROM CROSS-LINKED HYALURONIC ACID | 2013 |
|
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| CARBOHYDRATE CROSS-LINKING AGENT | 2016 |
|
RU2733145C2 |
| PHOTOSOLIDIFIED GEL BASED ON CROSS-LINKED HYALURONIC ACID AND METHOD OF ITS PREPARING | 1996 |
|
RU2197501C2 |
| COMPOSITION COMPRISING HYALURONIC ACID AND MEPIVACAINE | 2014 |
|
RU2670617C2 |
| INJECTION GEL PRODUCT | 2018 |
|
RU2783125C2 |
