HAEMOSTATIC POWDER Russian patent published in 2024 - IPC A61L15/22 A61L15/28 A61L15/32 A61K9/14 A61P7/04 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a haemostatic powder containing at least 10 wt.% agglomerates of particles, said agglomerates of particles have a diameter in range of 1–500 mcm and contain: (a) electrophilic polyoxazoline particles containing electrophilic polyoxazoline bearing at least 3 chemically active electrophilic groups and which is a poly[2-(ethyl/hydroxy-ethyl-amide-ethyl/NHS-ester-ethyl-ester-ethyl-amide-ethyl)-2-oxazoline] terpolymer with an activated side chain NHS (N-hydroxysuccinimide) containing 20% NHS-ester groups, which can react with amine groups in blood to form a covalent bond; and (b) nucleophilic polymer particles comprising a water-soluble nucleophilic polymer bearing at least 3 chemically active nucleophilic groups and which is a nucleophilic polyoxazoline, reduced cross-linked gelatin, nucleophilic polyethylene glycol, such as NH₂-PEG, gelatin or chitosan, which in the presence of water can react with chemically active electrophilic groups of electrophilic polyoxazoline to form a covalent bond between electrophilic polyoxazoline and a nucleophilic polymer, also relates to a method of preparing agglomerates of haemostatic particles from: (a) electrophilic polyoxazoline particles containing electrophilic polyoxazoline bearing at least 3 chemically active electrophilic groups and which is a poly[2-(ethyl/hydroxy-ethyl-amide-ethyl/NHS-ester-ethyl-ester-ethyl-amide-ethyl)-2-oxazoline] terpolymer with an activated side chain NHS (N-hydroxysuccinimide) containing 20% NHS-ester groups, which can react with amine groups in blood to form a covalent bond; and (b) nucleophilic polymer particles containing a water-soluble nucleophilic polymer bearing at least 3 chemically active nucleophilic groups and which is a nucleophilic polyoxazoline, reduced cross-linked gelatin, nucleophilic polyethylene glycol, such as NH2-PEG, gelatin or chitosan, which can react with chemically active electrophilic groups of electrophilic polyoxazoline to form a covalent bond between the electrophilic polyoxazoline and the nucleophilic polymer; wherein said method involves a step of combining 100 parts by weight of electrophilic polyoxazoline with 10–1000 parts by weight of nucleophilic polymer particles in the presence of a non-aqueous granulating liquid.

EFFECT: group of inventions provides development of a haemostatic powder containing agglomerates of particles, due to which a more homogeneous, strong gel is formed, which provides improved sealing properties.

14 cl, 11 tbl, 7 ex