FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and represents pharmaceutical formulations for oral administration of anti-sense oligonucleotide against SMAD7, pharmaceutically acceptable tablets for oral application of anti-sense oligonucleotide against SMAD7, as well as oral dosage form containing said antisense oligonucleotide and enteric coating containing ethyl acrylate-copolymer of methacrylic acid. Said pharmaceutical formulations, pharmaceutically acceptable tablets and oral dosage form is used for treating Crohn's disease, ulcerative colitis and other chronic inflammatory intestinal diseases in patient by oral administration.
EFFECT: present invention enables directed delivery of anti-sense oligonucleotide against SMAD7 terminal ileum and ascending colon division of patient for effective treatment of chronic inflammatory intestinal diseases.
23 cl, 7 dwg, 7 tbl, 9 ex
