ARTIFICIAL LEATHER Russian patent published in 2016 - IPC A61L27/60 A61L27/00 A61K31/4184 A61K31/4406 A61F2/10 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to method of producing artificial skin. Method of producing artificial skin, including epidermal basal membrane containing continuous dark plate (lamina densa) and anchor fibre, outgoing from lamina densa and derma, containing collagen fibres, which involves adding an inhibitor of matrix metalloproteinase and heparanase inhibitor to culture medium for formation of artificial leather, containing human keratinocytes epidermis and derma fibroblasts; culturing cells in culture medium for formation of artificial leather and formation of artificial leather. Artificial skin. Agent stimulating formation of dark plate (lamina densa) and anchor fibres associated with dark plate containing matrix metalloproteinase inhibitor and heparanase inhibitor. Agent stimulating formation of bulging on surface of cell membranes (fibripositors) and formation of dark plate (lamina densa) and anchor fibres associated with dark plate containing matrix metalloproteinase inhibitor and heparanase inhibitor. Agent stimulating formation of elastin fibres and formation of dark plate (lamina densa) and anchor fibres associated with dark plate containing matrix metalloproteinase inhibitor and heparanase inhibitor. Agent stimulating regeneration and recovery of epidermal basal membrane and derma and formation of dark plate (lamina densa) and anchor fibres associated with dark plate containing matrix metalloproteinase inhibitor and heparanase inhibitor.

EFFECT: method described above enables to obtain artificial skin, close to natural skin.

10 cl, 3 dwg, 1 tbl, 1 ex