METHOD FOR DIFFERENTIAL DIAGNOSIS OF DYSMETABOLIC NEPHROPATHY IN CHILDREN ASSOCIATED WITH TOXIC ACTION OF CADMIUM, LEAD, CHROMIUM AND PHENOL OF MAN-MADE ORIGIN, AND DYSMETABOLIC NEPHROPATHY OF NON-TOXIC NATURE Russian patent published in 2016 - IPC A61B8/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, ecology, toxicology and can be used for differential diagnosis in children of dysmetabolic nephropathy, associated with toxic action of cadmium, chromium, lead and phenol of technogenic origin and dysmetabolic nephropathy of non-toxic nature. Child's blood content of cadmium, lead, chromium and phenol is determined. If blood cadmium content is 1.4-2.0 times, lead - 1.2-1.5 times, chromium - 1.2-1.7 times, phenol - 1.3-4.0 times higher than reference/background, method includes genetic analysis of gene polymorphism CYPOX, RCYT 450, SULTA1. In presence of polymorphism in homozygotic and heterozygotic version of genes CYPOX, RCYT 450, SULTA1 method includes ultrasonic inspection in child of state of blood flow in subcapsular renal zone in colour Doppler imaging mode. If blood flow depletion in subcapsular renal zone is established, laboratory values are determined: level of total antioxidant activity of blood serum (CCA), level of Cu/Zn of dependent superoxide dismutase (Cu/Zn-SOD), level of glutathione peroxidase (GlPO) and hydroperoxides of lipids, absolute index of phagocytosis and phagocytic number. Upon exceeding level of CCA by 25-30 %, level of Cu/Zn-SOD by 30-50 %, GlPO by 30-50 %, hydroperoxides of lipids by 30-50 % and absolute phagocytosis and phagocytic number by 1.2 and 2.3 times, respectively. If child has said conditions, at least in form of 65 % of said laboratory values, child is diagnosed with dysmetabolic nephropathy, associated with toxic action of cadmium, lead, chromium and phenol of technogenic origin. In absence of such excess, child is diagnosed with dysmetabolic nephropathy of non-toxic nature.

EFFECT: method provides accurate differential diagnosis, taking timely therapeutic and preventive actions by taking into account most significant parameters.

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