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(19)

(11)

2 595 136

(13)

(51)

IPC

C07D265/30(2006-01-01)

C07D403/12(2006-01-01)

C07D405/12(2006-01-01)

C07D413/12(2006-01-01)

C07D413/14(2006-01-01)

C07D471/04(2006-01-01)

A61K31/4025(2006-01-01)

A61K31/496(2006-01-01)

A61K31/5375(2006-01-01)

A61K31/5377(2006-01-01)

A61P9/04(2006-01-01)

A61P9/12(2006-01-01)

(21) (22)

Application

2013146012/04, 2012-03-15

(24)

Start date

2012-03-15

(22)

Actual filing date

2012-03-15

(45)

Published

2016-08-20

(72)

Inventor

Iidzima ToruSugama KhirosiKavaguti TakayukiShen TszinkanKsia GuanksinKsie TsziyanshuKhiraj Miki

(73)

Holder

Mitsubisi Tanabe Farma KorporejshnShankhaj Farmasyutikalz Kholding Ko., Ltd.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUNDS Russian patent published in 2016 - IPC C07D265/30 C07D403/12 C07D405/12 C07D413/12 C07D413/14 C07D471/04 A61K31/4025 A61K31/496 A61K31/5375 A61K31/5377 A61P9/04 A61P9/12

Abstract RU 2595136 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula [I] and its pharmaceutically acceptable salts thereof. Compound of formula [I] possesses renin-inhibitory activity. In formula [I]

R¹ is C_3-6-cycloalkyl group; R denotes lower alkyl group or makes 5-6-member ring by binding with R²² at each end; T is a carbonyl group; Z is -O-, -NH- or single bond; and R³, R⁴, R⁵ and R⁶ are a hydrogen atom. Invention also relates to a pharmaceutical composition containing a compound of the invention, and to a compound of formula [II].

EFFECT: obtaining novel compounds of formula [I], having renin inhibitory activity.

11 cl, 93 tbl, 422 ex

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RU 2 595 136 C2

Authors

Iidzima Toru

Sugama Khirosi

Kavaguti Takayuki

Shen Tszinkan

Ksia Guanksin

Ksie Tsziyanshu

Khiraj Miki

Dates

2016-08-20—Published

2012-03-15—Filed